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5-MeO-DMT is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine).
5-MeO-DMT is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine). It can be found in a wide variety of trees and shrubs, often alongside DMT and bufotenine (5-HO-DMT).
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In Central and South America, some of the best known 5-MeO-DMT sources are Anadenanthera peregrina (yopo or cohoba) and Virola theiodora—both of which are traditionally harvested to make psychoactive snuff. It’s also found in the milky white venom of the Colorado River Toad (Bufo alvarius/Incilius alvarius) native to the southwestern United States and northwestern Mexico.
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In keeping with its ceremonial use among indigenous Amazonians, 5-MeO-DMT shows great promise in the treatment of certain medical conditions. Many people also find its effects to be personally useful or even life changing. Vaporizing or smoking 5-MeO-DMT powder is probably the most common route of administration. The next common is snorting or insufflation.
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Effects from vaporizing or smoking 5-MeO-DMT are usually felt within the first 30 seconds, peaking from 1-15 minutes and lasting for up to half an hour. A threshold dose is around 1-2 mg, while a moderate-to-strong dose is 5-10 mg.
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Insufflated, it may take up to five minutes to feel the effects, despite the higher dose ranges involved (threshold: 3-5 mg; moderate: 8-15 mg). Effects tend to peak after 10-30 minutes and subside from around 30-45. 5-MeO-DMT oral doses for swallowing are higher, with generally unreliable results. Other less common routes of administration include sublingual (under the tongue) and injection.
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5-MeO-DMT should not be taken with MAOIs, including some antidepressants. Combining them may cause severe hypertensive symptoms (elevated blood pressure, heart rate, and temperature), seizures, long-term kidney damage, serotonin syndrome, and death.
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Because of the somewhat unpredictable nature of 5-MeO-DMT, a sitter is definitely recommended. Short-term unconsciousness, respiratory depression, and delusional interactions with the environment are some of the things to watch out for. At the very least, it should be taken in a comfortable seated or lying position to avoid falling over.
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Those new to 5-MeO-DMT should start out with a low dose, weighed on a scale accurate to 0.002 g (2 mg). Since people tend to react differently to the same doses (and it’s not entirely clear why) caution is advisable even if you have prior experience of tryptamines.
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